More than one spousal / fiance visa sponsorship per your lifetime can raise a reasonable suspicion. Cross-border marriages and visa sponsorships are seen as exceptional by US immigration based on my perception on how immigration works.
Of course, if you sponsored somebody at age of 21, then they passed away and you're sponsoring somebody else at age of 60, that's different to sponsoring new immigrant within 5-10 years of sponsoring somebody else.
Even when you sponsor later in life it may open another can of worms, such as:
- Is US citizen sponsoring somebody for financial reward, since medical expenses etc increase as you get older?
- Are they sponsoring a disguised caretaker (especially if immigrant 10+ years younger)?
There's no 100% way of knowing what would happen. You may get more scrutiny, or you may not. It's a risk you and your new spouse may need to evaluate.