Jump to content
Sign in to follow this  
w¡n9Nµ7 §£@¥€r

Scientists unlock mystery of why some who get HIV never get AIDS

11 posts in this topic

Recommended Posts

Filed: Timeline

May 7, 2010 - Harvard/MIT researchers appear to have solved one of the great mysteries of HIV -- and may at last be on track to develop an effective AIDS vaccine.

The mystery is why about one in 200 people infected with HIV -- dubbed "elite controllers" -- never get AIDS. It's long been thought that solving this secret would lead to the Holy Grail of AIDS research: an effective vaccine.

Now researchers led by MIT's Arup Chakraborty, PhD, and Harvard's Bruce D. Walker, MD, report that elite controllers have a rare set of genes that allow their immune systems to unleash killer T cells with unusual powers. The findings come from an elegant series of experiments, including study of 1,100 elite controllers and 800 people with AIDS.

Normal killer T cells work as a team. It usually takes a swarm of these cells, which recognize different bits of a virus, to kill virus-infected cells. But this process is too slow to stop fast-mutating viruses such as HIV. The astonishing ability of HIV to change its spots via mutation is one reason the normal immune system can't control the virus.

The killer T cells in elite controllers don't need help. They knock off virus-infected cells all by themselves. Moreover, they are "broadly reactive" and can kill off mutant HIV variants as they arise.

There's a downside to having broadly reactive killer T cells: They don't always leave normal cells alone. This makes elite controllers more susceptible to autoimmune diseases.

But there's an upside, too. Elite controllers aren't just impervious to HIV. They're also protected against other fast-growing viruses such as hepatitis C virus.

As it turns out, normal people have a few of these "broadly reactive" killer T cells. A few may be all that are needed.

"We think they might be coaxed into action with the right vaccine," Chakraborty says in a news release.



Arup Chakraborty


Bruce Walker

Man is made by his belief. As he believes, so he is.

Share this post

Link to post
Share on other sites
Filed: Timeline

Sooner or later they were going to figure that HIV thingy out. And then there'll be the next little bug or whatever that takes down scores of people. It's an ongoing battle in which mother nature will ultimately always have the upper hand.


Man is made by his belief. As he believes, so he is.

Share this post

Link to post
Share on other sites
Filed: Timeline
Maybe we should all just give up and commit seppuku dog. If the entire human race disembowels itself in one go, all human viruses will be cured permanently.

I am a genius.

Well, that's kind of throwing the kid out with the bathwater. It's actually less genius than it might seem on the surface.

Share this post

Link to post
Share on other sites

Keep your ####### outta yo buddies a$$ might help! Never suck a ####### with shite on it!

"I swear by my life and my love of it that I will never live for the sake of another man, nor ask another man to live for mine."- Ayn Rand

“Your freedom to be you includes my freedom to be free from you.”

― Andrew Wilkow

Share this post

Link to post
Share on other sites

This makes elite controllers more susceptible to autoimmune diseases.

Ew! Do not want. :(

(RA, MS, teh lupus...etc)

we met: 07-22-01

engaged: 08-03-06

I-129 sent: 01-07-07

NOA2 approved: 04-02-07

packet 3 sent: 05-31-07

interview date: 06-25-07 - approved!

marriage: 07-23-07

AOS sent: 08-10-07

AOS/EAD/AP NOA1: 09-14-07

AOS approved: 11-19-07

green card received: 11-26-07

lifting of conditions filed: 10-29-09

NOA received: 11-09-09

lifting of conditions approved: 12-11-09

Share this post

Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
Sign in to follow this  
- Back to Top -

Important Disclaimer: Please read carefully the Visajourney.com Terms of Service. If you do not agree to the Terms of Service you should not access or view any page (including this page) on VisaJourney.com. Answers and comments provided on Visajourney.com Forums are general information, and are not intended to substitute for informed professional medical, psychiatric, psychological, tax, legal, investment, accounting, or other professional advice. Visajourney.com does not endorse, and expressly disclaims liability for any product, manufacturer, distributor, service or service provider mentioned or any opinion expressed in answers or comments. VisaJourney.com does not condone immigration fraud in any way, shape or manner. VisaJourney.com recommends that if any member or user knows directly of someone involved in fraudulent or illegal activity, that they report such activity directly to the Department of Homeland Security, Immigration and Customs Enforcement. You can contact ICE via email at Immigration.Reply@dhs.gov or you can telephone ICE at 1-866-347-2423. All reported threads/posts containing reference to immigration fraud or illegal activities will be removed from this board. If you feel that you have found inappropriate content, please let us know by contacting us here with a url link to that content. Thank you.
  • Create New...