Thank you for the reply.
I did a quick call to Ft Lauderdale and he said there would be no problem unless more than a year. He stated it would be a good idea to have something from the DR. or hospital in Medellin as she would just go through a secondary screening.
I also called USCIS and the agent stated, as well, that there would not be a problem. She would would go through secondary (so to think of layover time when getting a new ticket) and that she should get a letter from the Dr. or hospital. I asked if I should mail her a copy of the deed to our house and proof of bank account, etc and he stated it would be a good idea so things would go smoothly. BTW, I stated "infopass" to get to an actual person!
So it looks like everything will be OK as far as keeping her green card and being allowed in.
If a year or more overall, he stated to fly in to get a reentry permit for her next trip (or whatever its called) or visit the consulate in Colombia so her residence won't be cancelled. But if that long, there would be no problem of a quick trip here to get cleared and than go back.
Thanks again. I'm not even going to bring this up to her right now as she is too much of a mess right now, (I had to call the airline to cancel/but keep open her ticket) but at least I know she'll be allowed back, just a few more questions than normal at Customs and Immigration I suppose.