I visited the US on ESTA (for work) the week before my scheduled K-1 interview in Tokyo, zero issues. If anything, having that interview scheduled was a pretty compelling reason for me to go back, but it didn't even come up.
By then I had a total of 20+ visits to the US on ESTA, they might have more questions for a beneficiary with very few or no prior US visits, but I don't see why they'd throw up roadblocks for someone that has gone through the hoops up to that point.