Savka

Yes.  You can received another RFE for the I-130.  Or more than one.
 
The medical will affect the I-485, and yes, you can receive an RFE for that or another issue specific to the I-485.  For the medical specifically I would not worry too much over it.  Because the medical exam is time sensitive, it is probably better to wait to submit it if/when they ask for it or bring it to the interview.  This is actually the advice from USCIS, per the instructions for the I-485 (page 13):
 
 
https://www.uscis.gov/sites/default/files/document/forms/i-485instr.pdf
 

Hello everyone, 
I have a question I submitted I130 and I485 for my mother (I’m a citizen and my mom is currently in US) everything was fine, we did the fingerprints but now they sent me RFE for missing signature (I can’t believe that I missed a signature but I didn’t do a copy of the paperwork so my fault) 
my question is because I got a RFE for I130 can I can get a second RFE? 
Because I didn’t submit the medical exam paperwork I thought that I will have RFE for that but I’m afraid that too many things are wrong and they will deny my case
 If anyone have advice it will be greatly appreciated 
Thanks! 

I don’t think that you will have any problems, on my removing of conditions Biometric app. Letter, my name was misspelled. I did my fingerprints and I got so worried that I requested emergency app. at the local office and literally the woman there told me that it’s happen people makes mistakes and nobody can guarantee how my name will be spell on my new GC. Luckily my GC was correct