intestine liner helps weight loss

[Amby 490]

A US company is developing a removable liner for the intestine that mimics some aspects of weight-loss surgery, offering obese people a nonsurgical way to drop weight and combat the most common form of diabetes.

GI Dynamics Inc. of Lexington, Massachusetts, said its EndoBarrier is intended for morbidly obese people who want to avoid procedures such as gastric bypass surgery. The company presented research showing the device helps obese people lose weight and lower blood sugar levels.

The device lines part of the intestines with a thin material similar to Teflon, keeping food from touching the intestinal walls, the company said.

"Fundamentally what we're trying to do is mimic the bypass portion of a gastric bypass procedure. So instead of surgically bypassing the intestine, we're mechanically bypassing the intestine. And we're doing that with an impermeable membrane that lines the inside of the intestine," Stuart Randle, chief executive officer of privately held GI Dynamics, said..

How it works

Doing so appears to influence hormones relating to hunger, feeling full and blood glucose regulation, according to Dr Jan Willem Greve of Maastricht University Medical Centre in the Netherlands, who did company-funded research on the device.

It also may delay gastric emptying, which means food stays in the stomach longer and a person feels full longer.

Weight-loss surgery alters the digestive system's anatomy, reducing the volume of food a person can eat and digest. The most common type is gastric bypass, which makes the stomach smaller and takes food past part of the small intestine. This device does not change how much food a patient can eat.

The device is implanted through the mouth, down the throat, through the stomach and into the intestines. The lining covers about 60 cm of the 3.6-metre intestines.

It is being tested in clinical trials to treat obesity and type 2 diabetes. Greve presented findings from a small study at a medical meeting in Argentina on Friday.

How the study was done

Twenty-six people in the Netherlands had the device and 11 did not. All followed the same diet. People in both groups on average weighed more than 135 kg. After three months, those with the device lost an average of about 14 kg compared to 4.4 kg for the others.

The eight people with type 2 diabetes who got the device had their blood sugar levels drop significantly, Greve said.

Greve said side effects included minor nausea and vomiting in the week to 10 days after implantation.

Randle did not offer a timetable for bringing the device to market, but said it could be years. Gastric bypass surgery costs about $26 000. Randle said the cost for getting this device would be less than $10 000.

http://www.health24.com/news/Weight_manage...1-955,48117.asp

[HAL 9000 96]

I see, gastric emptying is delayed by the liner. I hope the glucose levels they checked went into the long term 'cause if you don't check for that the study could be useless. The intestines secrete a protein that signals your brain and your pancreas to increase insulin secretion when glucose levels reach a certain amount after eating.