I think it really is a case of keep sending in applications and treat your job hunt as a full time job.
I applied for any job I felt I could do whether it was in my field or not.
I kept 3 master resumes, each showing different aspects of my previous experience and qualifications. They were all truthful but played up different aspects of my skills. I would then tailor the best fitting master to the job I was applying for and make sure to keep a copy of which resume I sent for which job.
I finally applied for an admin job with a small company in my field. Three hours after I faxed my resume I got a call and was interviewed the following day. I was offered the job and will start with admin and move into IT training and some training with Microsoft and Intel for the technical side of the job. The good thing about a small company is that there is room to expand the job to fit the company's needs and make myself indispensable.
Don't just look for IT jobs but look for IT companies where you can use other transferable skills just to get your foot in the door.
I really didn't expect my first job in America to be in a field I was qualified for but it happened. I'm an ex nurse with a Masters in IT and will be working for in medical records IT systems.