It depends on your location and your chosen airline for transportation.
For me, we flew China Air, POE is Anchorage Alaska, and we live in Philly.
POE was uneventful. There are two lines, Visa holders vs. USC/PR. Your wife would line up at the long line along with the folks who visit the US, on business, work, student, k1, k3, cr1 visa etc. Wait for them to check and ask question about her purpose to come to America, why is she traveling by herself, is she a terrorist blah blah, it's just like going through a quick Visa Interview again. OR, they just look at your Visa in your passport and wave you through! the POE CBP officer will stamp your passport, staple the I-94 card back on your passport with the date stamp for immigration clearance/inspection purpose. You oughta make sure the have this I-94 card in your passport before you leave the Immigration desk, you will need it for the AOS later on. Then off you go, welcome to America.
Note: this is my own experience, in Anchorage Alaska. Keep in mind, the CBP Officer has the ultimate power to deny your wife's entrance if he is not happy with what he finds in your wife's file or any valid reason. This is rare, but happens! Also, do not forget to keep the "BROWN" Envelope which the consulate office will give to you when you get your Visa, keep that brown envelop with you during travel, you will need to hand it in at POE. Some folks accidently checked it in with their luggages, SOL, can't get through Immigration until you hand in that envelop. More information about the brown envelop if you need to know, just ask!
Personally, that's basically what would/could happen at POE. Ask Lurker, his wife should be traveling to the US soon or maybe already JUST entered the country. He would have a better and fresher memory of her POE.
Last but not least tip: I know you mentioned you won't be traveling with her due to work schedule, but if you did, you could have waited in the same line with your wife, instead of entering through the USC line. The CBP Officer will still check you and her both out! Everything I said here is my personal experience and giving you some of the worse case scenario just to prepare you, mentally

!!!! Good luck and I like how you work: think PINK baby!